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Elucidate the mechanims12/24/2023 Examples of these technologies include spinal cord stimulation (SCS) and dorsal root ganglion (DRG) stimulation for chronic low-back pain, transcutaneous magnetic stimulation (TMS) and vagus nerve stimulation (VNS) for migraine and cluster headache, and transcutaneous electrical nerve stimulation (TENS) for pain. Although several therapeutic devices for pain relief have received FDA Premarket Approval (PMA) or 510(k) clearance and are being disseminated clinically, many have shown variability in outcomes between individuals, or may reach a plateau in the pain relief they provide. The outcomes of this program have the potential to ignite significant improvements in device-based clinical therapies for pain relief. Therapeutic devices provide a significant opportunity to offer a class of non-opioid therapies for pain that reduces or eliminates the need for opioid prescription and can provide treatment options for those who have no other effective ways to manage their pain. The NIH HEAL Initiative aims to identify new, safer treatment options for pain management to improve quality of life and reduce the number of people exposed to the risks of opioids. It is expected that NIH HEAL Initiative recipients will cooperate and coordinate their activities after awards are made by participating in Program Director/Principal Investigator (PD/PI) meetings, including an annual HEAL Investigators Meeting, as well as other activities. ![]() ![]() The NIH HEAL Initiative will require a high level of coordination and sharing between investigators. More information about the HEAL Initiative is available at. The NIH HEAL Initiative bolsters research across NIH to (1) improve treatment for opioid misuse and addiction and (2) enhance pain management. This funding announcement is part of the NIH’s Helping to End Addiction Long-term (HEAL) Initiative to speed scientific solutions to the national opioid public health crisis. Teams are encouraged to consider objectives that will produce major advances in the understanding of device-based pain relief that are likely to improve strategies for pain management. Project goals should not be achievable with a collection of individual efforts or projects. Teams must leverage appropriate multi-disciplinary expertise to develop new principles and methods for experimentation, analysis, and interpretation. Program teams are expected to accomplish goals that require considerable synergy and collaborative interactions. ![]() This funding opportunity announcement (FOA) is designed to support interdisciplinary research teams of multiple PD/PIs to investigate the mechanisms of action of pain relief using FDA-approved or -cleared medical devices with the overall goal of optimizing therapeutic outcomes for these technologies. Through targeted research efforts, the NIH HEAL Initiative aims to support the development of safe and effective devices to treat pain with little or no addiction liability. Innovative scientific solutions to develop alternative pain treatment options are thus critically needed. This contributed to a significant and alarming epidemic of opioid overdose deaths and addictions. In recent decades, there has been an overreliance on the prescription of opioids for chronic pain despite their poor ability to improve function and high addiction liability. More than 25 million Americans suffer from daily chronic pain, a highly debilitating medical condition that is complex and difficult to manage.
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